IO Parallel Mini Bioreactors Fermenters

IO Parallel Mini Bioreactors Fermenters
Brand: Solaris Biotechnology Solaris Biotechnology
Product Code: IO
Availability: Pre-Order
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Benefits
  • Up to 24 units managed with one HMI with innovative PARALLEL process control LEONARDO: smart controller designed to provide an high level of automated management of the fermentation/cultivation processes
  • Batch, Fed batch or continous processes
  • Different gas mixing strategies with up to 5 TMFC
  • 23’’ (single unit) or 27’’ (multi system) multi touch HMI
  • Remote control via PC, tablet and smartphone for process management and after sale assistance
  • Powerful/ Accurate brushless motor, from 1 to 2000 RPM. Online absorbed Torques (Nm) and Power (W) measurements obtaining an indirect density indication of the culture broth
  • Modbus Digital Hamilton sensors
  • LEDA safe sterile sampling system. The needle free connector is designed to reduce the risk of contamination during sampling. The sterile combination of a syringe (3-5-10-30 ml) and a non return valve guarantees the sterility after sampling until the next use.
  • Compact and modular PCS (350x350x350 mm). Additional parameter in modular external boxes for future PCS upgrade Including dCO2, cell density, weight, peristaltic pumps, ect
  • N.4 assignable Watson Marlow pumps, all speed controlled in entry level
  • No water circulation. Thermoregulation performed through Peltier cell

 

Modbus Hamilton sensors

Why a digital sensor?

Hamilton sensors (including Cell Density) has been integrated into Solaris PCS and Leonardo software giving the user the benefit of having a unique platform.
Fully compensated digital sensors, store and transmit all relevant sensor data, including calibration and diagnostic information directly to Solaris Leonardo software.

 
pH

The electrolyte of the EasyFerm Bio sensors is prepressurized to prevent the diffusion of sample into the sensor. The Everef-F reference cartridge ensures that the reference electrolyte remains free of silver and precipitation of proteins.

dO2

The VisiFerm DO is the first optical oxygen sensor with integrated optoelectronics. The visiFerm requires less maintenance than a classical oxygen sensor as it does not have a mechanically sensitive membrane or a corrosive electrolyte.

ORP

The ORP sensor through a pre-pressurized reference electrolyte has a clogfree diaphragm.
The sensor ensures a stable measurement signals after steam sterilization, autoclavation and CIP cleanings qith almost drift-free measurement.

Conductivity

All wetted conductivity sensor parts are FDA approved, can be cleaned easily and withstand CIP cleanings and autoclavations. The sensor shows a very good linearity over a broad measuring range.

Optical density sensor (total and viable cell density)

ON LINE MEASUREMENT OF TOTAL CELL DENSITY
  • Simple online measurement of cell growth
  • Reliable values during the growth phase
  • Early detection of process deviations
The Dencytee sensor performs online measurement of total cell density in solution. The sensor is based on optical density, which measures the turbidity of the cell suspension. The measurement is made at NIR (near-infra red) wavelengths so it is insensitive to changes in media color. All particles and molecules that scatter light at 880 nm will be detected, including living and dead cells as well as cell debris. This measurement is effective after inoculation when cells are expanding quickly but concentrations are low, making capacitance-based readings less reliable.
 
ON LINE MEASUREMENT OF VIABLE CELL DENSITY
  • Increase yield and lower production costs
  • Detect changes in cell physiology with frequency scanning
  • Precisely control harvesting for continuous culturing
  • Early detection of process deviations

The Incyte sensor enables real-time, online measurement of viable cells in solution. The measurement is not influenced by changes in the media, microcarriers, dead cells or debris, and is designed for mammalian cell culture, yeast and high-density bacterial fermentation. Online measurement of viable cells makes it possible to detect events and respond in real time without sampling.

 

Leda sampling system

  • LEDA sterile single use sampling system up to 180 sterile sampling per batch.
  • Needlefree connector is designed to reduce the risk of contamination during sampling.
Technical specifications
Material VALOX resin (external) silicone (internal)
Autoclavable 121-133°C (up to 30 minutes)
Residual volume 0.04 mL
Flow rate 65 mL/minute

The sterile combination of a syringe (3-5-10-30 ml) and a non return valve guarantee the sterility after sampling until the next use.

 

Gas Mixing

Various controller and hardware configurations enable aeration strategies using air, oxygen, nitrogen or a mixture of these to enrich the air. The mass-flow controller allows the exact flow rate control of individual gases. The flexible aeration options integrated in the bioreactor permit a wide range of different application giving to this system a substantial versatility.

  • Thermal Mass Flow Controller in entry model
  • Gas mixing through TMFC+ solenoid valves or numbers of TMFC
  • Automatic gas mixing algorithms for simplified controls (4-gas, 3-gas, O2 enrichment, N2 enrichment)
  • Fluted sparger
 

Solaris Cube Series

Solaris new modular product design strategy decreases time to market and the number of unique parts in the product architecture increasing the number of product variants. The result is a lean, flexible and smart PCS.

Additional parameter in modular external boxes for future PCS upgrade Including dCO2, cell density, weight, peristaltic pumps, ect

 

User-friendly Software

The software is the user’s best friend in experimental design planning and performing trial runs, as well as analyzing and optimizing media and parameters for cultivation.
The graphical user interface enables you to select the software functions intuitively. Data extracted are compatible with Windows Excel. However, Solaris has developed Leonardo data viewer, a platform where to easily and quickly manage fermentation data.
The software is included in the fermenter supply and can be installed on unlimited number of client’s PC or laptop.

Do it parallel: smarter... faster

Leonardo can be used for process development (i.e. time-saving ∙ parallel fermentation approaches).
Up to 24 indipendent fermentations/cultivations can be carried out simultaneously.can be carried out simultaneously.
The graphical user interface enables you to select the software functions intuitively. Data extracted are compatible with Windows Excel. However, Solaris has developed Leonardo data viewer, a platform where to easily and quickly manage fermentation data.
The software is included in the fermenter supply and can be installed on unlimited number of client’s PC or laptop.

Parallel workflow
Parallel trends comparison
between units, current and old batches

Do it wireless!

Increased mobility: users can roam around lab or reaching office or home without losing their connection with the running batch.

Why to invest in this product:

Fast and Accurate, thermoregulation, without Water, Circulation, Parallel control, up to 24 units
 

IO typical applications includes the following:

Education & Basic research, Scale-up and scale-down studies, Process development and optimization

IO can be used for

Biopharmaceutical, Biofuels, Food industry, Bioremediation, Bioplastic, Cosmeceutical, Nutraceutical
 

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